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Medical Marketing and Media - Lipitor tops list of Rx searches online

admin — Mon, 05 Jan 2009 23:41:03 +0000

PFIZER’S LIPITOR was the most searched-for prescription drug on the Web in 2004, according to PharmacyChecker.com, a site that collects and reports on customer feedback regarding online and mail-order pharmacies.
PharmacyChecker.com examined more than 600,000 searches to its site by over 1 million consumers looking for low-cost prescription drugs during 2004.

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Mylan Receives Approval for Lisinopril and Lisinopril/HCTZIvax’s lisinopril gets tentative OKTeva Announces Approval Of Lisinopril Tablets And Lisinopril HCTZ TabletsGenerics firms win approval for lisinoprilEon Labs Receives Approval for Lisinopril/HCTZ Tablets

Of the top 20 most searched-for Rx drugs on the Web last year, 18 were brand-name drugs. Lisinopril and Atenolol were the only generics.-Stephen McGuire
Copyright CPS Communications Sep 2005
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Caribbean Update - Drug pulled after mystery deaths.(PANAMA)(Brief article)

admin — Wed, 31 Dec 2008 13:26:04 +0000

DRUG PULLED AFTER MYSTERY DEATHS. The government began removing a drug used to treat high blood pressure and heart failure from pharmacies, hospitals and clinics as a precautionary measure amid speculation that a contaminated batch may have …

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Chain Drug Review - Generics prescriptions

admin — Sun, 28 Dec 2008 23:56:02 +0000

* Generic medicines account for 53% of all prescriptions dispensed in the U.S.
* Generic pharmaceutical products are used to fill more than 1 billion prescriptions every year.

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* In 2004 the top 10 generic drugs, by the number of prescriptions dispensed, were hydrocodone/APAP, lisinopril, atenolol, amoxicillin, hydrochlorothiazide, furosemide oral, alprazolam, albuterol aerosol, metformin and cephalexin.
COPYRIGHT 2006 Racher Press, Inc.
COPYRIGHT 2008 Gale, Cengage Learning

Canadian Corporate News - Medicure Meets Primary Endpoints in Phase II Diabetic Hypertension Study.

admin — Mon, 22 Dec 2008 06:01:03 +0000

WINNIPEG, MANITOBA, Sep 14, 2005 (CCNMatthews via COMTEX) — Conference Call Today at 10:30 AM Eastern to Discuss Positive MATCHED Results

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Medicure Inc. (TSX:MPH)(AMEX:MCU), a cardiovascular drug discovery and development company, is pleased to announce that MC-4232 met primary blood pressure and metabolic endpoints in the Phase II MATCHED study. The study evaluated MC-4232, a combination of MC-1 and the ACE inhibitor, lisinopril, in the treatment of coexisting diabetes and hypertension. Based on these positive results, the Company plans to move forward with a pivotal Phase III …

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Medicines Used in Heart Failure

admin — Mon, 15 Dec 2008 12:36:04 +0000

Drugs to Control Sodium and Water Retention
Diuretics
Drugs which increase urine formation are useful in CHF.
Furosemide
It is a very potent drug used orally and intravenously to treat severe CHF and oedema in lungs due to Left Heart Failure. Usual dose is 40 to 80 mg per day. Drug causes loss of electrolytes, particularly potassium. Therefore, it is necessary to get extra potassium (as potassium chloride) during its regular use. One way to obviate loss of potassium is by giving another variety of drug along with furosemide. These drugs are called as Potassium-Sparing diuretics. These counteract the loss of potassium. Such drugs are:
Spironolactone is a combination of furosemide 20 mg and spironolactone 50 mg.
Triamterene (Frusemene) is a combination of furosemide 20 mg and triamterene 50 mg.
Torasemide (Dytor 10 mg). It is another potent diuretic.
Thiazides
For mild to moderate CHF, thiazides act as good diuretics allowing loss of sodium, potassium and water in urine. The same problem exists with their use and therefore potassium supplementation is necessary. Addition of a potassium-sparing diuretic along with a thiazide is quite common practice to reduce potassium loss for example ALDACTIDE which is a combination of hydroflumethiozide 25 mg and spironolactone 25 mg. BIDURET which is a combination of hydrochlorothiazide 50 mg and amiloride 5 mg. In some cases longer use of thiazide may cause impotency, poor control of diabetes, rise in blood levels of uric acid (gouty pains may occur) and lipids. Allergy may occur, occasionally.
Drugs that Provide Long Term Benefits In CHF
ACE-inhibitors
Captopril, (Capoten) Enalapril (Enace), Lisinopril (Listril), Ramipril (Ramace) are the drugs which decrease formation of chemicals aldosterone and angiotensin-II which are responsible for causing structural changes in the heart with CHF. Therefore, their use in low doses for a longer period alters the course of disease (unfortunately digoxin could not do so!). The size and thickness of heart muscles revert back to normal and pumping capacity improves without significant adverse effects. This has been proved in multicentric drug trails which show prolongation of a ‘good quality’ life in CHF. The chances of sudden death are reduced and episodes of CHF recurrences are less. Obviously, they are increasingly used nowadays. Patients who are unable tolerate ACE-inhibitors due to dry hacking cough, losartan, candesartan or valsartan is given.
Role of Beta-blockers: It is a parodox that a drug which worsens CHF has shown to be beneficial in long term for the same disorder, provided CHF is treated beforehand with the above drug in the absence of breathlessness and very low doses of metoprolol, carvedilol and bisoprolol are used. After 2 to 3 months the pumping capacity of heart increases and episodes of hospitalisation reduce. The only caveat is that use should be judicious and systolic dysfunction (poor heart contractions) is the underlying problems and the patient has mild to moderate CHF treated or compensated with routine drugs only.
Role of Other Drugs: Spironolactone acts as a mild diuretic but more importantly prevents heart muscle damage (fibrotic changes) when added to ACE-inhibitors in low doses of 12.5 to 25 mg per day. Its benefits are slow but steady. It should never be taken if there is kidney damage. In poor relaxation (diastolic phase) of heart, calcium channel blockers are effective.

Zestoretic - The Right Treatment for You?

admin — Thu, 11 Dec 2008 03:51:02 +0000

A common problem seen today in more and more people is that of high blood pressure. Often this is also referred to as hypertension. You may have come across the prescription drug Zestoretic, often prescribed by health care providers as a medical solution. However, if you are thinking of taking this treatment no doubt you have some concerns about it. We will investigate the most asked questions to see if this is the right answer for you.
Who should take Zestoretic?
This drug is actually a combination of a diuretic, or water pill, and an ACE (Angiotensin Converting Enzyme) inhibitor. Usually it will not be prescribed until the rehabilitation process has begun. Due to the potential fatal risk to the unborn child, pregnant women should never take Zestoretic. In a similar vein, if you are breastfeeding the same advice applies; there is too great a danger of the milk being affected. Should the following conditions be present then again, do not take this course:
Inability to urinate
Allergies to Hydrochlorothiazide or Lisinopril
Extreme sensitivity to ACE inhibitors
What is the correct way to take Zestoretic?
You should follow the instructions at all times. Unlike similar drugs, Zestoretic can be taken on a full or an empty stomach; usually once a day. If you forget to take a dose at the usual time then take it as soon as you remember. However if you are close to the time when normally you would be ready for the next dose, then do not take a double dosage. Even if you notice an improvement after a few days you should see the course right through to its completion; the reason for this is that Zestoretic works gradually but effectively.
How should I store Zestoretic?
You will be pleased to read that there are no special instructions for the storage of this drug; no need to keep it cool in the refrigerator. The normal advice for most pills applies here, store at room temperature away from too much dampness or heat, and of course keep them away from children.
What side effects should I know about?
As with all drugs, the potential of unpleasant side effects is there. In most cases this wont be a factor for you, but it is useful to have a list to refer to so that you can recognize them for what they are. Some are relatively minor and dont require you to stop taking the drug although you should see your doctor if they persist:
Distorted or blurred vision
Mild skin rash
Pain in the stomach together with nausea
Spells of dizziness
Diarrhea or constipation
However if you encounter any of the symptoms below you must you stop taking the drug at once and see your doctor urgently:
Symptoms of flu
Strange numbness or tingles in the skin
Dry mouth combined with nausea or drowsiness
Severe red skin rash
Fainting
Jaundice together with severe stomach pain and nausea
Excessive or insufficient urinating
It is extremely rare for such side effects to occur; most patients have reported no side effects of any kind, minor or major.
Summary
To wrap this article up, you are no doubt aware that Zestoretic has a good reputation in fighting against high blood pressure. It is simple to take either with, or without food, meaning that it is not too intrusive on those with active lives. Just as you would with all prescription drugs, exercise due caution and consult with your doctor. That being said you ought to find Zestoretic sufficiently effective in keeping your high blood pressure under control.

Medications ~ Ten Tips For Responsible Use

admin — Tue, 09 Dec 2008 12:21:03 +0000

All medications, which include over-the-counter preparations, vitamin and mineral supplements, and herbal preparations, are potentially dangerous. Following some simple rules will not only reduce your chance of having a problem, but should reduce your cost as well.

1. Always shop around for medications there is a significant difference in cost from pharmacy to pharmacy. Check both online and offline sources. For example, several of my patients have realized a significant cost savings by using the Costco pharmacy as well as online Canadian pharmacies. Should you choose to use a Canadian pharmacy, please keep abreast of any laws that may affect your purchase.

2. Always check to see if a generic equivalent is available. Today, there are very few medications on the market where generics are not acceptable.

3. If you can, have your prescription filled for 90 days. It will cost less than if you bough 30 days worth over 3 months. One of the reasons is that pharmacies charge a filling fee for each prescription filled.

4. Will you medication allow you to take a half-tab? For example, if you are taking lisinopril 20mg, you can purchase 40mg tablets and break them in half a savings of 50%. Always check with your health care provider and/or pharmacist firstnot all medications can be broken. Also, consider those nifty little pill cuttersthey work wonderfully.

5. Do you really have to take all that medication in the first place? The best advice I can give you is to put everything into a bag and take it with you to your appointment. Make sure that you and your provider are on the same page when it comes to medications/supplements that you are taking. This is especially true when you are seeing more than one prescribing provider. You may have duplicates that you are unaware of. Always askdo I really need this?

6. Keep an up-to-date list of your medications with you at all times.

7. It is your responsibility to learn the names of your medications and why you are taking them! Most likely, your provider does not know what you mean by the little pink pill or the white capsule. There are literally dozens of each.

8. Check your medications before you leave the pharmacy. If something does not look right, ask about it right then. DO NOT take something you are unfamiliar with.

9. Follow label directions. If you are taking something for osteoporosis, chances are you were told to take it with a full glass of water, sitting upright while avoiding any other food or fluids for 30 minutes. They were not making it up! This goes for the labels on over-the-counter preparations. This is one time that if a little is good, a lot must be better can be a dangerous thought.

10. Another very important tip. If at all possible, it is in your best interest to have a primary care provider. Ideally, he or she will coordinate your care with specialists, and keep track of all the medications you are on. If you have a complete profile on record, then between your one primary provider, and your one pharmacist, any problems in your medications should be picked up.

11. This bonus tip comes from a lesson taught to me by a wonderful patient of mineIf you and your partner both take medication, do NOT mix them up. It can have serious consequences!

While proper nutrition and exercise are the mainstays of treatment for most health challenges, medication use is sometimes unavoidable. Make sure you need them; know what they are and how to take them. Follow directions, and dont share! Most of all, always seek to understand what you are taking and what its suppose to do for you. Your body will thank you.

Heart Attack ��” Causes, Symptoms and Medication

admin — Fri, 05 Dec 2008 22:21:02 +0000

A heart attack occurs when blood flow to a section of heart muscle becomes blocked. If the flow of blood isnt restored quickly, the section of heart muscle becomes damaged from lack of oxygen and begins to die.
Heart attack is a leading killer of both men and women in the United States. But fortunately, today there are excellent treatments for heart attack that can save lives and prevent disabilities. Treatment is most effective when started within 1 hour of the beginning of symptoms.
What exactly is a heart attack? Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat ” called an arrhythmia - that causes a severe decrease in the pumping function of the heart. A blockage that is not treated within a few hours causes the affected heart muscle to die.
Here are signs that can mean a heart attack is happening:
Chest discomfort. Most heart attacks involve discomfort in the center of the chest that lasts more than a few minutes, or that goes away and comes back. It can feel like uncomfortable pressure, squeezing, fullness or pain.
Discomfort in other areas of the upper body. Symptoms can include pain or discomfort in one or both arms, the back, neck, jaw or stomach.
Shortness of breath with or without chest discomfort.
Other signs may include breaking out in a cold sweat, nausea or lightheadedness
What Causes Heart Attack?
Atherosclerosis
Atherosclerosis is a gradual process in which plaques (collections) of cholesterol are deposited in the walls of arteries. Cholesterol plaques cause hardening of the arterial walls and narrowing of the inner channel (lumen) of the artery. Arteries that are narrowed by atherosclerosis cannot deliver enough blood to maintain normal function of the parts of the body they supply.
Atherosclerosis and heart attack
Occasionally the surface of a cholesterol plaque in a coronary artery may rupture, and a blood clot forms on the surface of the plaque. The clot blocks the flow of blood through the artery and results in a heart attack (see diagram below). The cause of rupture that leads to the formation of a clot is largely unknown, but contributing factors may include cigarette smoking or other nicotine exposure, elevated LDL cholesterol, elevated levels of blood catecholamines (adrenaline), high blood pressure, and other mechanical and biochemical forces.
Many different medicines are used to treat and prevent heart attacks. Nitroglycein helps reduce chest pain. You may also receive strong medicines to relieve pain.
Antiplatelet medicines help prevent clot formation. Aspirin is an antiplatelet drug. Another one is clopidogrel (Plavix).
Beta-blockers (such as metoprolol, atenolol, and propranolol) help reduce the strain on the heart and lower blood pressure.
ACE inhibitors (such as ramipril, lisinopril, enalapril, or captopril) are used to prevent heart failure and lower blood pressure.
Signs and symptoms of a heart attack in women may be different or less noticeable than heart attack symptoms in men. In addition to the symptoms above, heart attack symptoms in women can include:
Abdominal pain or “heartburn”
Clammy skin
Lightheadedness or dizziness
Unusual or unexplained fatigue
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Inhibace for HBP and congestive heart failure.

admin — Mon, 01 Dec 2008 10:21:03 +0000

Cilazapril (Inhibace) is an ACE inhibitor used for the treatment of high blood pressure and congestive heart failure. It controls blood pressure and reduces symptoms of congestive heart failure by relaxing blood vessels and by making the heart pump more efficiently.
For treatment of blood pressure, Inhibace may be used alone or in combination with diuretics known as thiazide diuretics (e.g., Hydrochlorothiazide) when one medication has not been found to control blood pressure satisfactorily. For treatment of congestive heart failure, it is used in addition to Digoxin or thiazide diuretics or both.
What is high blood pressure?
When you have high blood pressure, or hypertension, the force of blood against your artery walls is too strong. High blood pressure can damage your arteries, heart, and kidneys, and lead to atherosclerosis and stroke. Hypertension is called a “silent killer” because it does not cause symptoms unless it is severely high and, without your knowing it, causes major organ damage if not treated.
What is congestive heart failure?
The development of heart failure usually means that your heart’s ability to pump blood has weakened, so it can’t circulate enough blood to meet your body’s needs. Shortness of breath, fatigue and leg swelling may result. When fluid builds up, heart failure is called congestive. Sometimes the heart becomes too stiff to fill properly, and that also can lead to heart failure.
How is Inhibace taken?
Recommended doses range from 0.5 mg to 10 mg once daily, depending on the condition being treated as well as the person’s liver and kidney function. Inhibace should be taken at the same time each day.
Who shouldn’t take Inhibace?
You should not use this medication if you:
have an allergy to Cilazapril or any ingredients in it
have a history of angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any ACE inhibitors (e.g., Captopril, Enalapril, Fosinopril, Lisinopril, and others)
have ascites (swollen abdomen due to liver problems)
are pregnant
Does Inhibace have any side effects?
While taking this medication you may or may not experience these side effects:
dry cough
headache
diarrhea
loss of taste
nausea
unusual tiredness
Although rare you should seek medical help immediately if you experience any of the symptoms listed below:
sudden difficulty swallowing or breathing
fever and chills
hoarseness
swelling of face, mouth, hands, or feet (signs of angioedema)
stomach pain, itching of skin, or yellow eyes or skin
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Water Pill Works Best for High Blood Pressure

admin — Thu, 27 Nov 2008 02:26:03 +0000

April 5, 2005 — African-Americans are roughly three times as likely as whites to die of illnesses caused by high blood pressure.
Their increased risk is so great that what defines good blood pressure control is now lower for African-Americansgood blood pressure control is now lower for African-Americans than for whites, but new research shows that, in this group, water pills remain the drug of choice for the initial treatment of high blood pressure.
Using data from a landmark high blood pressure study, researchers showed that the oldest and cheapest blood pressure medications work betterlandmark high blood pressure study, researchers showed that the oldest and cheapest blood pressure medications work better as the initial treatment of high blood pressure, in both African-Americans and other races, than newer, more expensive drugs.
The findings show that thiazide-type diuretics, known as water pills, which cost just pennies a pill, are a better choice for the initial treatment of high blood pressure than the newer drugs, known as ACE inhibitors and calcium-channel blockers.
Is Blood Pressure Treatment Color-Blind?
Though nearly one in three American adults has high blood pressure,one in three American adults has high blood pressure, the figure is closer to one in two for African-Americans.
Because of this, the American Heart Association and other health groups recommend more aggressive blood pressure treatment for African-Americans than for other racial groups. The normal goal of treatment is to reduce blood pressure to below 140/90. But the goal for African-Americans is now 130/80.
In the newly published study, researchers analyzed data from a subgroup of participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Their goal was to look at the risk of heart disease and death from heart disease in African-Americans with high blood pressure taking one of the three commonly prescribed medications.
When first published in 2002, ALLHAT challenged the pervasive thinking that newer blood pressure drugs worked better to treat high blood pressure and prevent some forms of heart disease than water pills, which have been used to treat high blood pressure for many decades. The ALLHAT study showed that a water pill worked better.
ALLHAT researcher Jackson T. Wright Jr., MD, PhD, says the trial has not affected clinical practice to the extent that he had hoped.
“The message has not really gotten out,” he says. “There has been a slight increase in diuretic use but not to the extent that one would anticipate from the data that are now available.”
Participants in the ALLHAT study, conducted between 1994 and 2002, took one of three drugs to lower their blood pressure, a leading cause of heart disease. They were given one of three commonly prescribed blood pressure medications: the diuretic Hygroton, the ACE inhibitor lisinopril, or the calcium-channel blocker Norvasc.